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APOLIPOPROTEIN E 4
Descriptors Found:
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DeCS
Descriptor
English
:
Apolipoprotein E4
Descriptor
Spanish
:
Apolipoproteína E4
Descriptor
Portuguese
:
Apolipoproteína E4
Synonyms
English
:
Apo E epsilon 4
Apo E-4
Apo E4
ApoE4
Apolipoprotein E-4
Apo E 4
Apolipoprotein E 4
Tree Number:
D10.532.091.500.750
D12.776.070.400.500.750
D12.776.521.120.500.750
Definition
English
:
A major and the second most common isoform of
apolipoprotein
E. In
humans
, Apo E4 differs from
APOLIPOPROTEIN E3
at only one residue 112 (
cysteine
is replaced by
arginine
), and exhibits a lower resistance to denaturation and greater propensity to form folded intermediates. Apo E4 is a risk factor for
ALZHEIMER DISEASE
and
CARDIOVASCULAR DISEASES.
History Note
English
:
2007 (1982)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
52268
Unique Identifier:
D053327
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
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